...one of the reasons why we try to minimize this potentially fattening combo of high fat and high carbohydrate meals is because of the very same synergistic insulin release that has been described above. In 1996, when Dr. Holt and colleagues were formulating those famous insulin index charts, they noticed that foods containing refined carbohydrates and fats seemed to generate a disproportionate insulin response relative to the actual carbohydrate content as well as the glycemic index of the meal. This indicated that meals high in fat and carbohydrate could promote a nasty case of hyperinsulinemia.

This is the very same hyperinsulinemia that prevents the mobilization of fats from the storage depots of the adipose tissue to the metabolic furnaces of the muscle where they can be burned for energy; the very same hyperinsulinemia that, when combined with high blood levels of fat, can cause uptake of both fat and carbohydrate into the adipose tissue for fat building.
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http://www.t-nation.com/readTopic.do?id=461947

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