......The presence of some rare alleles and haplotypes indicated Asian genetic inflow. On the basis of HLA class I profile and supported by historical and anthropological data, we suggest that the Bulgarian population is characterized by the features of the Southern European anthropological type with some influence of other groups such as Asians, Turks, Armenians. Migrations and assimilation of many different ethnic groups are the major factor determining the genetic diversity of our population.....

The presence in Bulgarians of A*0207, A*36 and B*56 alleles and A*02-B*38-Cw12 and A*24-B*51-Cw*14 (HF 0,008) haplotypes, found also in Asian populations ( 13, 32, 40) might be explained by the invasion of Turkic tribes between the 7th and the 15th century on the Balkan Peninsula. Further support is provided by our previous observations sowing presence of some characteristic for Asians DRB1-DQB1 associations in the Bulgarian population ( 12). Additionally the Bulgars are considered to be of Central Asian origin and some of these alleles and haplotypes might be incorporated as a result of migrations, conquest and assimilation between different Central and South Asians Turkic people. Although some alleles (A*36,B*56), previously found in the Mongolians (40), are also detected in the Bulgarians, the two populations are showed to be quite distant from each other in all kinds of analyses performed. ..

"Observation of some Oriental alleles, such as B*5201, confirms the contribution of Orientals to the genetic diversity of our population, as defined previously based on HLA class I generic data. Additionally, allele variants considered as rare for Europeans could be correlated to specific population groups and could make populations comparisons more discriminative. Alleles A*0211, A*3004, A*8001, B*2707, and DRB1*0410 have been detected in different Asian populations and probably were incorporated into Bulgarians during the invasion by Turkic tribes between the 7th and 15th centuries on the Balkan Peninsula.

"Additionally, two haplotypes considered to be of Eurasian origin were
detected in the Bulgarians with a frequency of 0.0091:A*02011-B* 0801-DRB1* 03011 (A*02-B*08-DRB1*0301, observed with the highest frequency in the Mongolians and less commonly in some of the Europeans) and A*2402-B*1801-DRB1*1104 (A*24-B*18-DRB1*1104, found in the Macedonians, Armenians and Italians)."

Редактирано от джинrиби на 08.02.07 22:03.