Scientists claim that antimatter is the costliest material to make. In 2006, Gerald Smith estimated $250 million could produce 10 milligrams of positrons (equivalent to $25 billion per gram); in 1999, NASA gave a figure of $62.5 trillion per gram of antihydrogen. This is because production is difficult (only very few antiprotons are produced in reactions in particle accelerators), and because there is higher demand for other uses of particle accelerators. According to CERN, it has cost a few hundred million Swiss Francs to produce about 1 billionth of a gram (the amount used so far for particle/antiparticle collisions).

Several NASA Institute for Advanced Concepts-funded studies are exploring whether it might be possible to use magnetic scoops to collect the antimatter that occurs naturally in the Van Allen belt of the Earth, and ultimately, the belts of gas giants, like Jupiter, hopefully at a lower cost per gram.