HIV cure
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HIV cure
the man who had HIV and now does not
Cannon works with mice given human immune systems, since normal mice cannot get HIV. In one study, she took human stem cells, treated them to have the CCR5 mutation, and injected them into a group of mice, with another set of animals given untreated stem cells as a control. Then she infected both groups with HIV. The result, as published in Nature Biotechnology in July 2010: The control group got sick and died. The mice given the mutation fought off the virus and remained healthy.
....
Steven Deeks, a professor of medicine at the University of California, San Francisco, and a doctor at San Francisco General Hospital’s Positive Health Program—the newest name for the old Ward 86, the first-ever outpatient AIDS clinic—was among the few to appreciate the significance of Hütter’s display. “I said, ‘Wow, this is interesting. Why doesn’t anyone seem to care?’ ” Another was Jeffrey Laurence, director of the Laboratory for AIDS Virus Research at Weill Cornell Medical College and a senior scientific consultant for AMFAR. “I thought it was the most exciting thing I’d heard about since the discovery of the virus,” he says. “I couldn’t believe people didn’t take notice.” Laurence wrote an editorial about the Berlin Patient in The AIDS Reader. He received two letters. “It basically got ignored.”
....
The AIDS Establishment, like many Establishments, tends to be suspicious of outsiders. Here comes a young doctor, not even prominent at his own hospital, who by his own admission knew next to nothing about AIDS, doing something never done before. As more of the research community became aware of Hütter’s claims, the prevailing view was: Who is this guy?
Robert Gallo, a co-discoverer of HIV, devoted his opening address at a major conference in December 2009 to an attack on Hütter’s results. Gallo simply didn’t believe them and warned that only a pathologist could declare the patient cured—once the patient was dead. Hütter, scheduled to speak at the same event, quickly amended his presentation. As he defended his results to a panel of skeptics, he showed the new slide: “Do we have to cut this patient into slices?” it asked.
....
In fact, the Berlin Patient did appear in the Times—on page A12. The short article included quotes from Anthony Fauci, the director of the NIH’s National Institute of Allergy and Infectious Diseases and the world’s most important gatekeeper of AIDS research. Unlike other experts, Fauci accepted that Brown had been cured. He just didn’t think it was anything to get excited about. “It’s very nice, and it’s not even surprising,” he said—meaning that if you take away someone’s immune system and give him a new one resistant to HIV, it’s logical that he would be cured of AIDS. “But it’s just off the table of practicality.”
....
While the pharmaceutical industry has sunk hundreds of millions of dollars into developing AIDS treatments, most drug companies are sitting out cure research. (One big exception is Merck, which is funding studies of some of its drugs’ possible uses in eradication; Gilead is also looking at its compounds for cure candidates.) It’s no mystery why. “The whole field suffers from the lack of a business model,” says Jeff Sheehy, a San Francisco activist and CIRM board member. “A cure may make sense from a public-policy point of view, but not to a company.” Unlike treatment, which must be taken daily for life, a cure would be a one-time intervention. “It’s not that it’s sinister and they don’t want a cure. But it doesn’t fit.”
ебаси:)
he who packs your capsules controls your destiny.
Cannon works with mice given human immune systems, since normal mice cannot get HIV. In one study, she took human stem cells, treated them to have the CCR5 mutation, and injected them into a group of mice, with another set of animals given untreated stem cells as a control. Then she infected both groups with HIV. The result, as published in Nature Biotechnology in July 2010: The control group got sick and died. The mice given the mutation fought off the virus and remained healthy.
....
Steven Deeks, a professor of medicine at the University of California, San Francisco, and a doctor at San Francisco General Hospital’s Positive Health Program—the newest name for the old Ward 86, the first-ever outpatient AIDS clinic—was among the few to appreciate the significance of Hütter’s display. “I said, ‘Wow, this is interesting. Why doesn’t anyone seem to care?’ ” Another was Jeffrey Laurence, director of the Laboratory for AIDS Virus Research at Weill Cornell Medical College and a senior scientific consultant for AMFAR. “I thought it was the most exciting thing I’d heard about since the discovery of the virus,” he says. “I couldn’t believe people didn’t take notice.” Laurence wrote an editorial about the Berlin Patient in The AIDS Reader. He received two letters. “It basically got ignored.”
....
The AIDS Establishment, like many Establishments, tends to be suspicious of outsiders. Here comes a young doctor, not even prominent at his own hospital, who by his own admission knew next to nothing about AIDS, doing something never done before. As more of the research community became aware of Hütter’s claims, the prevailing view was: Who is this guy?
Robert Gallo, a co-discoverer of HIV, devoted his opening address at a major conference in December 2009 to an attack on Hütter’s results. Gallo simply didn’t believe them and warned that only a pathologist could declare the patient cured—once the patient was dead. Hütter, scheduled to speak at the same event, quickly amended his presentation. As he defended his results to a panel of skeptics, he showed the new slide: “Do we have to cut this patient into slices?” it asked.
....
In fact, the Berlin Patient did appear in the Times—on page A12. The short article included quotes from Anthony Fauci, the director of the NIH’s National Institute of Allergy and Infectious Diseases and the world’s most important gatekeeper of AIDS research. Unlike other experts, Fauci accepted that Brown had been cured. He just didn’t think it was anything to get excited about. “It’s very nice, and it’s not even surprising,” he said—meaning that if you take away someone’s immune system and give him a new one resistant to HIV, it’s logical that he would be cured of AIDS. “But it’s just off the table of practicality.”
....
While the pharmaceutical industry has sunk hundreds of millions of dollars into developing AIDS treatments, most drug companies are sitting out cure research. (One big exception is Merck, which is funding studies of some of its drugs’ possible uses in eradication; Gilead is also looking at its compounds for cure candidates.) It’s no mystery why. “The whole field suffers from the lack of a business model,” says Jeff Sheehy, a San Francisco activist and CIRM board member. “A cure may make sense from a public-policy point of view, but not to a company.” Unlike treatment, which must be taken daily for life, a cure would be a one-time intervention. “It’s not that it’s sinister and they don’t want a cure. But it doesn’t fit.”
ебаси:)
he who packs your capsules controls your destiny.