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| Тема |
 Ново генетично изследване. |
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| Автор |
джинrиби (пристрастен) |
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| Публикувано | 02.09.07 14:44 |
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Asen Zlatev1, Milena Ivanova2, Snejina Michailova2, Anastasia Mihaylova2 and Elissaveta Naumova2
(1) University Hospital “Alexandrovska”, 1 Georgy Sofiisky Street, Sofia, 1431, Bulgaria
(2) Central Laboratory of Clinical Immunology, University Hospital “Alexandrovska”, 1 Georgy Sofiisky Street, Sofia, 1431, Bulgaria
Received: 15 November 2006 Accepted: 5 May 2007 Published online: 2 June 2007
Abstract Recently Bulgarian Bone Marrow Donors Registry (BBMDR) has been established and since August 2005 it has been a member of Bone Marrow Donors Worldwide. Currently the number of healthy donors included in the BBMDR is relatively low. All donors included in the BBMDR are typed for HLA-A, -B, -DRB loci. Phylogenetic analysis based on HLA allele frequencies shows that Bulgarians were characterized with closest genetic similarity to Macedonians, Greeks, Romanians, Cretans and Sardinians in comparison to the other European and Mediterranean populations. On the contrary the second largest ethnic minority–the Roma were the closest to the other Roma populations and North Indians. These differences were due to the predominance of alleles and haplotypes that are specific for the Asian and the other Roma populations. These specific genetic profiles in the Bulgarian ethnic minorities justify the need of an adequate representation of minorities in BBMDR. Future directions for BBMDR development are discussed, including an increase of the total number of donors and these for ethnic minorities, as well the enhancement of the level of resolution of the HLA typing for the donors in the registry.
Keywords Bulgarian Bone Marrow Donor Registry - Bulgarians - HLA alleles - HLA haplotypes - Roma
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