Since I have designed this "Big Y" test by myself I can confirm that the enrichment assay is designed to cover about 18 Mb and I took special care for tweaking it so that the final coverage is in fact around 10MB. This was confirmed by a couple of test runs that have been done at Illumina. No such testing has been done in the FTDNA lab yet. However FTDNA is planning on doing 15000 of those tests on the HiSeq machines which means that they'll combine quite a lot of samples on a single run with "DNA barcoding". I am very worried that this will bring up a lot of crosstalk which will lead to confusing results across the combined samples. David Mittelmann didn't even get the numbers right for the WTY so I doubt that he'll be able to do the correct math for the Next Gen sequencing. In either case customers will be excited about the price and will not care about quality.