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| Тема |
 synthetic opioids |
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| Автор | efktr (Нерегистриран) | |
| Публикувано | 19.06.05 22:20 |
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na kakvo popadnah dnes znachi. citiram ot wikipedia:
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Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is roughly 10,000 times stronger than Morphine. It is marketed under the trade name Wildnil as a tranquilizer for large animals. Carfentanyl is intended for animal use only, as it is extremely toxic to humans.
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ne e istina prosto. heroin za kitove. sled 10 godini na heroin moje i da mojesh da go probvash sravnitelno bezopasno.
but wait, there's more!
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Tramadol is an opioid used as an analgesic for treating moderate to severe pain. It is a synthetic agent, unrelated to other opioids, and appears to have actions on the GABAergic, noradrenergic and serotonergic systems.
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The mechanism of action of tramadol has yet to be fully elucidated, but it is believed to work through modulation of the GABAergic, noradrenergic and serotonergic systems. Tramadol [and its metabolite, known as M1] have been found to bind to μ-opioid receptors (thus exerting its effect on GABAergic transmission), and to inhibit reuptake of 5-HT and noradrenaline.
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koeto oznachava, ako niakoi ne razbira, che tova e medikament suchetavasht, obrazno kazano, deistvieto na nai-modernite antidepresanti s deistvieto na klasicheskia opiat. ako mu slojat i malko po-goliam afinitet za D2 dopamin receptorite si stava napravo speedball. unbelievable. kakvo li sa mislili tia hora kato sa go sintezirali tova? i kak sa go licenzirali kato legalen medikament vuobshte.. no te nemcite si imat tradicia v taia nasoka - nemski farmacevti sa izolirali morfina, nemskata farmacevtichna kompania bayer e proizvela heroina, nemski farmacevti sa sintezirali metadona (po poruchka na goering mejdu drugoto).
i poslednia netipichen opiat v spisuka e lydol-a (pethidine, demerol, meperidine)...
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Pethidine has effects similar to morphine, but has very little effect on cough or diarrhea. It also tends to cause restlessness instead of sedation. Pethidine's analgesic effect is more rapid than morphine's, but shorter (2-4 hours). In addition, it has a slight antimuscarinic effect.
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..koito ima strukturni shodstva s kokaina ("..cause restlessness instead of sedation.."), durji malko, e nevrotoxichen (edin ot metabolitite - normeperidine, ako cirkulira dostatuchno dulgo v kruvta dovejda do parkinsonovi simptomi i ako postoi oshte malko - do permanentno uvrejdane, a imenno parkinson's disease) i koito, ot edinia mi incidenten opit s 80mg, e ebahti veselbata.
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synthetic opioids
