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Bumetanide (trade names Bumex or Burinex) is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there is substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.[1]
Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).[1]
In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, that quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates. Bumetanide is therefore currently under evaluation as a prospective antiepileptic drug.[2] -
Много е мощен този диуретик, не знам.
Слаби диуретици ми действат добре - Tomatoes, cranberries, pineapples and grapes are all rich in water, and thus are good diuretic foods. Cabbage, carrots, beets and asparagus are vegetables with known diuretic properties as well.
WARNING. Bumex (bumetanide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion.
На тези деца им трябват минерали и електролити, а много силен диуретик може да ги обезводни. Може би някакви слаби диуретици биха били
по-подходящи, но за някои определени случаи - например за които е доказано,
че точно това им е проблема - suggesting elevated intracellular chloride (Cl-)i в мозъка,
може този много силен диуретик да помогне, ако се дава под лекарски
контрол и се следи за бъбречната функция и за калия. М'чи те аутистите, особено тези
които са наистина много засегнати, не са добре и с бъбреците, което означава,
че трябва да са лекувани бъбреците преди да се дава такъв силен диуретик.
Редактирано от dorka14 на 08.02.14 09:48.
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