BIOCHEMICAL ANTENATAL SCREENING TEST
FOR DOWN'S SYNDROME

Tripple test : AFP / HcG / Estriol - at 15-18 weeks of pregnancy is indicative of high risk for Down's syndrome. In the fetus test is based on the principle that fetuses at risk for Down's syndrome are biochemically immature hence their values are different than normal fetuses at the same gestational age. If the serum test is positive, fetal chromosomal studies are indicated. Elevated Sr.AFP is indicative of possibility of Neural Tube Defects and GI tract anomalies.
SPECIMEN : 2 ml of serum in sterile bulb. Please give details regarding maternal age weight, gestational age by ultrasound.

WHO NEEDS GENETIC COUNSELLING ?

WHO NEEDS GENETIC COUNSELLING ?

Patients with bad obstetric history

Family H/O abnormal births

Maternal age above 35 years

Consanguine marriage

Maternal diseases, anxiety

Exposure to X-ray, Drugs and infections in Pregnancy

Abnormal ultrasound findings.

Communities at risk for genetic disorder e.g. Thalassaemia

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