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| Тема |
 Нивалин и алергия? |
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| Автор |
kkrekk (efir) |
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| Публикувано | 22.09.20 12:43 |
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А ЗНАЕТЕ ЛИ, ЧЕ НИВАЛИНЪТ Е МНОГО ИНТЕРЕСНО ЛЕКАРСТВО?
ДРУГОТО МУ ИМЕ Е ГАЛАНТАМИН.
ПОЛУЧАВАЛ ЛИ Е НЯКОЙ СТРАНИЧНИ ЕФЕКТИ ОТ НИВАЛИНА КАТО АЛЕРГИЯ МИ Е ВЪПРОСЪТ.
С РЕЦЕПТА ЛИ СЕ ПРОДАВА В АПТЕКИТЕ Е ДРУГИЯТ МИ ВАЖЕН ВЪПРОС. Едва ли. Но по втория начин се намира, това е ясно.
Питам, ЗАЩОТО ПОЛУЧИХ С АЛЕРГИЯТА СТРАНИЧНИ ЕФЕКТИ - жестоки МУСКУЛНИ КРАМПИ. И блок на мускулатурата на краката. Минава, но бавно. Алергозанът не помага никак. Карам на почти пълен глад, вода и други течности.
И имах чувството, че са ме отровили. Тогава пиех направени навън кафета. На най-различни места. Доколкото знам нивалинът се продава и в течен вид. Притесни ме това в статията на английски език.
Organophosphate poisoning
The toxicity of organophosphates results primarily from their action as irreversible inhibitors of acetylcholinesterase.[31]
Inhibiting acetylcholinesterase causes an increase in acetylcholine, as the enzyme is no longer available to catalyze its breakdown.[31]
In the peripheral nervous system, acetylcholine accumulation can cause an overstimulation of muscarinic receptors followed by a desensitization of nicotinic receptors.[31]
This leads to severe skeletal muscle fasciculations (involuntary contractions).[31]
The effects on the central nervous system include anxiety, restlessness, confusion, ataxia, tremors, seizures, cardiorespiratory paralysis, and coma.[31]
As a reversible acetylcholinesterase inhibitor, galantamine has the potential to serve as an effective organophosphate poisoning treatment by preventing irreversible acetylcholinesterase inhibition.[31]
Additionally, galantamine has anticonvulsant properties which may make it even more desirable as an antidote.[31]
Research supported in part by the US Army has led to a US patent application for the use of galantamine and/or its derivatives for treatment of organophosphate poisoning.[31]
The indications for use of galantamine in the patent application include poisoning by nerve agents "including but not limited to soman, sarin, and VX, tabun, and Novichok agents".
Galantamine was studied in the research cited in the patent application for use along with the well-recognized nerve agent antidote atropine. According to the investigators, an unexpected synergistic interaction occurred between galantamine and atropine in an amount of 6 mg/kg or higher. Increasing the dose of galantamine from 5 to 8 mg/kg decreased the dose of atropine needed to protect experimental animals from the toxicity of soman in dosages 1.5.times the dose generally required to kill half the experimental animals.[32]
ОСВЕН ТОВА...
Galantamine, (sold under the brand name Razadyne among others), is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments.[2][3]
It is an alkaloid that has been isolated from the bulbs and flowers of Galanthus caucasicus (Caucasian snowdrop), Galanthus woronowii (Voronov's snowdrop), and some other members of the family Amaryllidaceae, such as Narcissus (daffodil), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily).[4]
It can also be produced synthetically.
Studies of usage in modern medicine began in the Soviet Union in the 1950s. Galantamine was isolated for the first time from bulbs of Galanthus nivalis (common snowdrop) by the Bulgarian chemist D. Paskov and his team in 1956.[5]
The active ingredient was extracted, identified, and studied, in particular in relation to its acetylcholinesterase (AChE)-inhibiting properties.[6][7] The first industrial process was developed in 1959.[8][9]
However, it was not until the 1990s when full-scale synthesis was upscaled and optimized.[10]
Обърнах внимание на думата АЛКАЛОИД в началото на английската справка.
See there copy:
Предварително благодаря на отзовалите се.
Редактирано от kkrekk на 22.09.20 13:19.
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